Blar i forfatter "Brækkan, Sigrid Kufaas"

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    • Acute infection as a trigger for incident venous thromboembolism: Results from a population- based case- crossover study 

      Grimnes, Gro; Isaksen, Trond; Tichelaar, Ynse Ieuwe Gerardus Vladimir; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-21)
      Background:<br> A bidirectional relation exists between acute infection and immobilization, and both are triggers for venous thromboembolism (VTE). To what extent the association between infection and VTE‐risk is explained by immobilization is unknown. <br>Aims:<br> To investigate the impact of hospitalization with acute infection on the VTE‐risk in patients with and without concomitant ...

    • Associations between Common and Rare Exonic Genetic Variants and Serum Levels of 20 Cardiovascular-Related Proteins: The Tromsø Study 

      Solomon, Terry; Smith, Erin N.; Matsui, Hiroko; Brækkan, Sigrid Kufaas; Wilsgaard, Tom; Njølstad, Inger; Mathiesen, Ellisiv B.; Hansen, John-Bjarne; Frazer, Kelly A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-21)
      Background—Genetic variation can be used to study causal relationships between biomarkers and diseases. Here, we identify new common and rare genetic variants associated with cardiovascular-related protein levels (protein quantitative trait loci [pQTLs]). We functionally annotate these pQTLs, predict and experimentally confirm a novel molecular interaction, and determine which pQTLs are associated ...

    • Atherosclerotic risk factors and risk of myocardial infarction and venous thromboembolism; Time-fixed versus time-varying analyses. The Tromsø Study 

      Småbrekke, Birgit; Balteskard Rinde, Ludvig; Hindberg, Kristian; Mathiesen Hald, Erin; Vik, Anders; Wilsgaard, Tom; Løchen, Maja-Lisa; Njølstad, Inger; Mathiesen, Ellisiv B.; Hansen, John-Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-16)
      <i>Background:</i> Single measurements of modifiable risk factors may underestimate associations with outcomes in cohorts. We aimed to compare risk estimates of myocardial infarction (MI) and venous thromboembolism (VTE) by atherosclerotic risk factors during long follow-up using time-fixed analyses without and with correction for regression dilution and time-varying analyses.<p> <p><i>Methods:</i> ...

    • Atrial Fibrillation and Cause-Specific Risks of Pulmonary Embolism and Ischemic Stroke 

      Hald, Erin Mathiesen; Rinde, Ludvig Balteskard; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Njølstad, Inger; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-29)
      <p><i>Background</i>: Atrial fibrillation (AF) is a well‐established risk factor for ischemic stroke (IS). Emerging evidence also indicates an association between AF and pulmonary embolism (PE). Because IS may potentially mediate the observed risk of PE in AF, we aimed to assess the impact of AF on the cause‐specific risks of PE and IS in a large cohort recruited from the general population.</p> ...

    • Atrial fibrillation and future risk of venous thromboembolism:the Tromsø study 

      Enga, Kristin Fjeldstad; Rye Holmboe, Ina; Mathisen Hald, Erin; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • C-reactive protein and risk of venous thromboembolism: Results from a population-based case-crossover study 

      Grimnes, Gro; Isaksen, Trond; Tichelaar, Ynse Ieuwe Gerardus Vladimir; Brox, Jan; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-19)
      Long-term, low-grade inflammation does not seem to be a risk factor for venous thromboembolism. The impact of acute inflammation, regardless of cause, on risk of venous thromboembolism is scarcely studied. We aimed to investigate the impact of acute inflammation, assessed by C-reactive protein, on short-term risk of venous thromboembolism. We conducted a case-crossover study of patients with venous ...

    • C1 inhibitor deficiency enhances contact pathway–mediated activation of coagulation and venous thrombosis 

      Grover, Steven P.; Kawano, Tomohiro; Wan, Jun; Tanratana, Pansakorn; Polai, Zsofia; Shim, Young J.; Snir, Omri; Brækkan, Sigrid Kufaas; Dhrolia, Sophia; Kasthuri, Rohan R.; Bendapudi, Pavan K.; McCrae, Keith R.; Wolberg, Alisa S.; Hansen, John Bjarne; Farkas, Henriette; Mackman, Nigel (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-11)
      C1 inhibitor (C1INH) is a multifunctional serine protease inhibitor that functions as a major negative regulator of several biological pathways, including the contact pathway of blood coagulation. In humans, congenital C1INH deficiency results in a rare episodic bradykinin-mediated swelling disorder called hereditary angioedema (HAE). Patients with C1INH deficiency–associated HAE (C1INH-HAE) have ...

    • Cardiorespiratory fitness and future risk of venous thromboembolism 

      Evensen, Line Holtet; Isaksen, Trond; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-25)
      <i>Background</i> - Cardiorespiratory fitness (CRF) is a strong predictor of future arterial cardiovascular disease and premature mortality. However, there are limited data on the association between CRF and the risk of incident venous thromboembolism (VTE).<p><p> <i>Objectives</i> - To investigate whether estimated CRF (eCRF) was associated with the risk of incident VTE in a cohort recruited ...

    • Cardiovascular risk factors and risk of venous thromboembolism 

      Brækkan, Sigrid Kufaas (Doctoral thesis; Doktorgradsavhandling, 2010-01-28)
      Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is a common disease, with serious short- and long-term complications and a potential fatal outcome. Despite the knowledge of several inherited and acquired risk factors for VTE, still 30-50 % of the VTE events occur in the absence of obvious predisposing factors. Traditionally, arterial and venous thrombosis has ...

    • Chronic obstructive pulmonary Disease and risk of mortality in patients with venous thromboembolism - the Tromsø Study 

      Børvik, Trond; Brækkan, Sigrid Kufaas; Evensen, Line; Brodin, Ellen Elisabeth; Morelli, Vania Maris; Melbye, Hasse; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-30)
      <i>Background</i> - Previous studies have shown increased mortality in venous thromboembolism (VTE) patients with chronic obstructive pulmonary disease (COPD), but it is unknown to what extent the association is influenced by the severity of COPD and physical inactivity.<p> <p><i>Objectives</i> - This article investigates whether COPD, and stages of COPD, influenced the risk of mortality after a ...

    • Combined effect of high factor VIII levels and high mean platelet volume on the risk of future incident venous thromboembolism 

      Hansen, Ellen-Sofie; Edvardsen, Magnus; Aukrust, Pål; Ueland, Thor; Hansen, John Bjarne; Brækkan, Sigrid Kufaas; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-29)
      Background - High factor VIII (FVIII) levels and large platelets, as reflected by a high mean platelet volume (MPV), are separately associated with increased risk of venous thromboembolism (VTE). Whether the combination of high FVIII levels and large platelets has a supra-additive effect on VTE risk is unknown.<p> <p>Objectives - We aimed to investigate the joint effect of high FVIII levels and ...

    • Combined effects of five prothrombotic genotypes and cancer on the risk of a first venous thromboembolic event 

      Skille, Hanne; Paulsen, Benedikte; Hveem, Kristian; Gabrielsen, Maiken Elvestad; Brumpton, Ben Michael; Hindberg, Kristian; Gran, Olga Vikhammer; Rosendaal, Frits Richard; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-16)
      Background - The role of combined prothrombotic genotypes in cancer‐related venous thromboembolism (VTE) is scarcely studied. We aimed to investigate the impact of a 5‐single nucleotide polymorphism (SNP) score on the risk of VTE in patients with and without cancer using a population‐based case‐cohort.<p> <p>Methods - Cases with a first VTE (n = 1493) and a subcohort (n = 13 072) were derived ...

    • Combined effects of plasma von Willebrand factor and platelet measures on the risk of incident venous thromboembolism 

      Edvardsen, Magnus; Hansen, Ellen-Sofie; Hindberg, Kristian; Morelli, Vania Maris; Ueland, Thor; Aukrust, Pål; Brækkan, Sigrid Kufaas; Holtet Evensen, Line; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-23)
      Plasma von Willebrand factor (VWF) and platelet reactivity are risk factors for venous thromboembolism (VTE), and VWF can promote hemostasis by interaction with platelets. In this study, we explored the combined effects of plasma VWF and platelet measures on the risk of incident VTE. A population-based nested case-control study with 403 cases and 816 controls was derived from the Tromsø Study. VWF, ...

    • Complement activation assessed by the plasma terminal complement complex and future risk of venous thromboembolism 

      Høiland, Ina Isabella; Liang, Robin Amanda; Brækkan, Sigrid Kufaas; Pettersen, Kristin; Ludviksen, Judith K; Latysheva, Nadezhda; Snir, Omri; Ueland, Thor; Hindberg, Kristian; Mollnes, Tom Eirik; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-28)
      <i>Background</i>- It remains uncertain whether activation of the complement system, assessed by the soluble terminal C5b‐9 complement complex (plasma TCC), is associated with future risk of incident venous thromboembolism (VTE).<p> <p><i>Objectives</i>- To investigate the association between plasma levels of TCC and future risk of incident VTE in a nested case‐control study, and to explore ...

    • Complement factors B, D, C3bBbP and risk of future venous thromboembolism 

      Skjeflo, Espen Waage; Evensen, Line Holtet; Jensen, Søren Beck; Latysheva, Nadezhda; Michelsen, Annika Elisabet; Ueland, Thor; Brækkan, Sigrid Kufaas; Hindberg, Kristian Dalsbø; Snir, Omri; Mollnes, Tom Eirik; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-07)
      The complement system appears to be involved in the pathogenesis of venous thromboembolism (VTE).<p> <p>We investigated the association of complement factors (CF) B, D, and the alternative pathway convertase, C3bBbP, measured at inclusion, with the risk of future VTE in a nested case-control study; 380 VTE patients and 804 age- and sex-matched controls derived from the Tromsø study. Odds ratios ...

    • Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors 

      Thibord, Florian; Klarin, Derek; Brody, Jennifer A.; Chen, Ming-Huei; Levin, Michael G.; Chasman, Daniel I.; Goode, Ellen L.; Hveem, Kristian; Teder-Laving, Maris; Martinez-Perez, Angel; Aïssi, Dylan; Daian-Bacq, Delphine; Ito, Kaoru; Natarajan, Pradeep; Lutsey, Pamela L.; Nadkarni, Girish N.; de Vries, Paul S.; Cuellar-Partida, Gabriel; Wolford, Brooke N.; Pattee, Jack W.; Kooperberg, Charles; Brækkan, Sigrid Kufaas; Li-Gao, Ruifang; Saut, Noemie; Sept, Corriene; Germain, Marine; Judy, Renae L.; Wiggins, Kerri L.; Ko, Darae; O'Donnell, Christopher J.; Taylor, Kent D.; Giulianini, Franco; De Andrade, Mariza; Nøst, Therese Haugdahl; Boland, Anne; Empana, Jean-Philippe; Koyama, Satoshi; Gilliland, Thomas; Do, Ron; Huffman, Jennifer E.; Wang, Xin; Zhou, Wei; Manuel Soria, Jose; Carlos Souto, Juan; Pankratz, Nathan; Haessler, Jeffery; Hindberg, Kristian Dalsbø; Rosendaal, Frits R; Turman, Constance; Olaso, Robert; Kember, Rachel L.; Bartz, Traci M.; Lynch, Julie A.; Heckbert, Susan R.; Armasu, Sebastian M.; Brumpton, Ben Michael; Smadja, David M.; Jouven, Xavier; Komuro, Issei; Clapham, Katharine R.; Loos, Ruth J F; Willer, Cristen J.; Sabater-Lleal, Maria; Pankow, James S.; Reiner, Alexander P.; Morelli, Vania Maris; Ridker, Paul M.; Vlieg, Astrid van Hylckama; Deleuze, Jean-François; Kraft, Peter; Rader, Daniel J.; Psaty, Bruce M.; Skogholt, Anne Heidi; Emmerich, Joseph; Suchon, Pierre; Rich, Stephen S.; Vy, Ha My T; Tang, Weihong; Jackson, Rebecca D.; Hansen, John Bjarne; Morange, Pierre-Emmanuel; Kabrhel, Christopher; Trégouët, David-Alexandre; Damrauer, Scott M.; Johnson, Andrew D.; Smith, Nicholas L. (Journal article; Tidsskriftartikkel, 2022)
      <p><i>Background:</i> Venous thromboembolism (VTE) is a life-threatening vascular event with environmental and genetic determinants. Recent VTE genome-wide association studies (GWAS) meta-analyses involved nearly 30 000 VTE cases and identified up to 40 genetic loci associated with VTE risk, including loci not previously suspected to play a role in hemostasis. The aim of our research was to expand ...

    • Cystatin C is associated with risk of venous thromboembolism in subjects with normal kidney function - the Tromso study 

      Brodin, Ellen Elisabeth; Brækkan, Sigrid Kufaas; Vik, Anders; Brox, Jan; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Background Previous studies have shown an association between impaired kidney function, assessed by cystatin C-based estimated glomerular filtration rate, and venous thromboembolism. The aim of this study was to investigate whether serum cystatin C was associated with a risk of venous thromboembolism among subjects with normal kidney function in a prospective population-based study. Design and ...

    • D-Dimer Measured at Diagnosis of Venous Thromboembolism is Associated with Risk of Major Bleeding 

      Johnsen, Håkon Sandbukt; Hindberg, Kristian; Bjøri, Esben; Brodin, Ellen Elisabeth; Brækkan, Sigrid Kufaas; Morelli, Vania Maris; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-25)
      Identification of patients at risk of major bleeding is pivotal for optimal management of anticoagulant therapy in venous thromboembolism (VTE). Studies have suggested that D-dimer may predict major bleeding during anticoagulation; however, this is scarcely investigated in VTE patients. We aimed to investigate the role of D-dimer, measured at VTE diagnosis, as a predictive biomarker of major bleeding. ...

    • D-Dimer Measured At First Venous Thromboembolism Is Associated With Future Risk Of Cancer 

      Gran, Olga Vikhammer; Brækkan, Sigrid Kufaas; Paulsen, Benedikte; Skille, Hanne; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12)
      D-dimer >5000 ng/ml at incident VTE is associated with a higher risk of subsequent cancer within one and two years. High D-dimer levels are also associated with more aggressive tumor biology and poor prognosis in these patients. As D-dimer is routinely measured in the assessment of suspected VTE, it may be a useful surrogate marker for the presence of an underlying malignancy. Our findings may suggest ...

    • Diagnostic Blood Biomarkers for Acute Pulmonary Embolism: A Systematic Review 

      Wikan, Vårin Eiriksdatter; Tøndel, Birgitte Gladsø; Morelli, Vania Maris; Brodin, Ellen Elisabeth; Brækkan, Sigrid Kufaas; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-06)
      (1) Background: The current diagnostic algorithm for acute pulmonary embolism (PE) is associated with the overuse of CT pulmonary angiography (CTPA). An additional highly specific blood test could potentially lower the proportion of patients with suspected PE that require CTPA. The aim was to summarize the literature on the diagnostic performance of biomarkers of patients admitted to an emergency ...